Document 0793
 DOCN  M94B0793
 TI    HIV lymphomas frequently carry mutations in the c-myc protein (Meeting
       abstract).
 DT    9412
 AU    Spangler G; Gaidano G; Hamdy N; Dalla-Favera R; Magrath I; Bhatia K;
       Pediatric Branch, NCI, Bethesda, MD 20892
 SO    Proc Annu Meet Am Assoc Cancer Res; 35:A1141 1994. Unique Identifier :
       AIDSLINE ICDB/94602827
 AB    Non-Hodgkin's lymphomas, particularly high grade B cell lymphomas, are
       the most frequent malignancies diagnosed in patients infected with HIV.
       We have previously reported the occurrence of point mutations in the
       protein coding region of c-myc in approximately 60% of SNCL in non-HIV
       infected patients. We have now screened the entire coding region of
       c-myc in thirty HIV lymphomas and assessed the integrity of the c-myc
       protein. Our results indicate that the c-myc protein is mutated in 50%
       of the HIV lymphomas and 75% of small non-cleaved HIV lymphomas. Among
       14 other histological subtypes tested (3 large cell non-cleaved, 3 Ki-1
       positive and 8 immunoblastic lymphomas) only 2 immunoblastic lymphomas
       carried c-myc mutations. Unlike intronic mutations, coding region
       mutations were seen in some tumors that lacked a myc/Ig translocation.
       However, among 19 tumors with a myc/Ig translocation, 9/11 which lacked
       EBV had a c-myc mutation, whereas only 2 of 8 EBV positive tumors
       contained a translocation. These mutations, unlike those that occur in
       the intron, were also seen in tumors with no evidence of c-myc
       translocation. The implications of these mutations in the genesis of HIV
       lymphomas will be discussed.
 DE    Cell Transformation, Neoplastic/GENETICS  Chromosome Aberrations  Gene
       Expression Regulation, Neoplastic/PHYSIOLOGY  Gene Frequency  Human
       Lymphoma, AIDS-Related/*GENETICS  Mutation/*GENETICS  Proto-Oncogene
       Proteins c-myc/*GENETICS  MEETING ABSTRACT

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       protected by Copyright Law (Title 17, U.S.Code).